Transcription attenuation amplifies collateral vulnerabilities in rifampicin-resistant ...
Source: Nature
Published:
<p>Mycobacterium tuberculosis (Mtb) acquires resistance to rifampicin (Rif) through mutations in the β-subunit of RNA polymerase (RNAP) that prevent the drug from binding. The most common mutation is a single amino acid substitution, βS450L, that confers antibiotic resistance. This mutation also res