Rosie O'Donnell Responds to Trump's AI Deepfake Video Mocking 'Trump Derangement Syndrome'

It’s no secret that Donald Trump is a fan of AI-generated images. After posting a recent deepfake infomercial of himself dressed as “Dr. Trump,” giving celebs such as Rosie O’Donnell, John Leguizamo , Whoopi Goldberg , Robert De Niro , Edward Norton , and Julia Roberts the cure for Trump Derangement Syndrome (FYI it’s “Turn off fake news. Say your prayers . And if you ever feel anxious, just have a Diet Coke.”), O’Donnell is clapping back against the president’s TDS PSA.

Trump’s now-viral clip begins with, “Have you or someone you know been diagnosed with TDS? The symptoms can be relentless. Fortunately, I’m Dr. Trump, and I have a treatment plan. Let’s hear what some of my patients have to say.”

AI O’Donnell is the first Hollywood star Trump features . In an almost unbelievably realistic clip, fake Rosie reveals, “I have been suffering for over a decade. And after listening to Dr. Trump, I can see some results.” The video also features the other celebrities making faux TDS admissions such as, “I’ve been suffering for years. I really didn’t believe there was help out there. That was when I came across this video on TV, and “I really thought I was a lost cause.”

Not one to shy away from controversy, O’Donnell (the real Rosie) isn’t staying silent. After watching the AI deepfake, the actress has plenty to say the president’s message.

O’Donnell responded to the clip by posting her own statement (on Instagram), “He’s quite ill - and getting worse daily. The 25th Amendment exists for exactly this reason. Remove. Impeach. Convict.”

She also included a screenshot of the video from a social media post with a that reads, “The incoming lawsuit from @rosie @johnleguizamo is going to be awesome!”

While O’Donnell has not revealed publicly whether a lawsuit is in the works, it looks like her fans and friends are here for it. Actress and activist Alexandra Billings commented, “I’m begging you to sue him. I’ve never asked you for anything…I’m literally begging you,” and forensic clinical psychologist Dr. Leslie Dobson added, “Let’s go. I’ll assess the world’s emotional damages in the lawsuit.”

But the didn’t end there. Support for O’Donnell poured in, with one fan writing, “Ain’t nobody gonna ever break Rosie” and others saying, “Team Rosie always!,” “Yeah, lawyer up, I love you . You’re so brave” and “Can you imagine the gloriousness if @rosie ends up being the one to take him down. Absolutely epic!”

Of course, the were somewhat different on the president’s post . One Trump supporter wrote, “This AI is getting out of hand, but I love it!” while another said, “Best doc in the country!”

As of now, there is no confirmation potential lawsuits from the actress or any other celebrity featured in the video.

This story was originally published by Parade on Jul 3, 2026, where it first appeared in the News section. Add Parade as a Preferred Source by clicking here.